The Saskatoon Fire Department was called to a motor vehicle accident about five minutes south of Saskatoon on Sunday shortly after 7:30 p.m.
One vehicle was found upright on the highway and the other one on its roof in the ditch.
All occupants were removed, and fire crews helped set up a landing zone for the STARS helicopter.
The accident was at Highway 11 and Victor Road. Ground ambulance also responded. No other details were provided.