Anyone with information regarding the whereabouts of Jolie Gardypie-Wuttunee and/or Arly Bighead is asked to contact the Saskatoon Police Service, to remain anonymous contact Crime Stoppers or in an emergency 9-1-1.
The Saskatoon Police say the two teens have been reported missing and are believed to be in a vulnerable state.
Jolie Gardypie-Wuttunee is 16 years old, and Arly Bighead who is 14 years old, are believed to be together and possibly travelling in a 2016 Grey Ford Escape with a Saskatchewan License plate 638MSQ.
They are believed to be in Saskatoon.